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Kua Liu on Muck Rack

Kua Liu

As seen in: Nature
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Articles

Thymopentin enhances adenoviral oncolytic therapy by regulating macrophages and CD8 + T cells

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By Lingkai Kong, Yan Liu, Peng Wang, Jiannan Qiu, Qilei Xin, Dan Zhou, Wencui Liu, Fangkun Zhao, Junnan Wu, Xiaosong Gu, Junhua Wu, Chunping Jiang, Kua Liu, Huawei Cui
| Nature Verified
Abstract Oncolytic viruses are cancer therapies that selectively replicate in tumors, deliver therapeutic genes, and stimulate immune responses. Combining these viruses with immune-boosting agents could enhance their effectiveness. Thymopentin (TP5), an immune-modulating peptide, may enhance the antitumour efficacy of ADV. We tested TP5 combined with adenovirus type 5 in tumor models, measuring tumor growth and immune changes using flow cytometry and antibody-based cell depletion.
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