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Articles by Kuak Ping Ng
Centella asiatica and Butterfly Pea ( Clitoria ternatea ) in Oral Beauty Supplements and Functional Beverages: A Critical Review of Human Evidence, Bioavailability, Safety and Formulation
Submitted: 27 October 2026 You are already at the latest version Centella asiatica and butterfly pea (Clitoria ternatea) are increasingly combined in oral beauty supplements and blue-coloured functional beverages in Asia. A 2026 randomised trial reported that oral Centella extract reduced wrinkle depth, and a 2023 review proposed microencapsulated butterfly pea extract as a functional food ingredient.
Orthosiphon stamineus (Misai Kucing) for Diabetes: A Translational Reappraisal of Human Evidence, Dose, Mechanistic Assays and Safety
Submitted: 27 October 2026 You are already at the latest version A 2022 systematic review concluded that Orthosiphon stamineus (misai kucing, Java tea) could be an antidiabetic agent, based on 31 studies that were almost entirely in vitro or in animals. This review examines their translation to people. No randomised trial of O. stamineus on glucose or HbA1c was found.
Multi-Target In Vitro Enzyme-Inhibitory Activity of Lipo Crystal, a Liposomal Vitamin C, Pineapple and White Tomato Nutraceutical Powder: Inhibition of Collagenase, Xanthine Oxidase, Tyrosinase and Hyaluronidase
Submitted: 26 October 2026 You are already at the latest version Multi-ingredient nutraceutical powders are widely marketed for skin health, yet most are characterised against a single enzyme target, and few are evaluated as the finished, reconstituted article that a consumer actually ingests. We report an integrated in vitro characterisation of Lipo Crystal, a spray-dried sachet powder combining liposomal vitamin C with pineapple and white tomato extracts.
Oak Galls ( Quercus infectoria , Manjakani) in Women's Intimate Health: A Critical Review of the Clinical Evidence, Effects on the Vaginal Ecosystem and Safety
This version is not peer-reviewed. Submitted: 26 October 2026 You are already at the latest version Oak galls, known in Malaysia and Indonesia as manjakani, are traditionally used for vaginal discharge, laxity and postpartum care, and are widely sold in feminine washes and tightening products. A 2023 systematic review of oak gall phytochemistry and bioactivity did not address these uses.
Labisia pumila (Kacip Fatimah) Extracts: Aligning Extraction Research with the Clinical, Regulatory and Safety Evidence—A Critical Review
This version is not peer-reviewed. Submitted: 25 October 2026 You are already at the latest version Extraction studies of Labisia pumila (kacip fatimah) usually select solvents by yield, phenolic acid content and antioxidant assays. A representative study recommended supercritical carbon dioxide with 70% ethanol–water co-solvent for the leaves of var. pumila. This review asks whether such optimisation produces extracts comparable to those with human, regulatory or safety evidence.
Tiger Milk Mushroom ( Lignosus rhinocerus TM02) in Allergic Rhinitis: A Critical Reappraisal of the First Randomised Controlled Trial and the Human Evidence Base
This version is not peer-reviewed. Submitted: 25 October 2026 You are already at the latest version The first randomised controlled trial of tiger milk mushroom (Lignosus rhinocerus TM02) in allergic rhinitis reported significant symptom relief associated with interleukin-5 downregulation. This review places that trial within the human evidence for the mushroom and reappraises its findings.
Endogenous Ascorbate Synthesis Confounds Oral Bioavailability Testing of Liposomal Vitamin C in Sprague Dawley Rats: Evidence from a Four-Arm Pharmacokinetic Study Including an Untreated Control
Submitted: 24 October 2026 You are already at the latest version Background: Liposomal vitamin C is marketed almost entirely on enhanced oral bioavailability, and preclinical rodent pharmacokinetic studies are routinely commissioned to support that positioning. Rats, unlike humans, retain a functional L-gulonolactone oxidase and synthesise ascorbate endogenously.
Seven Years of Third-Party Quality Data on a Commercial Tongkat Ali ( Eurycoma longifolia ) Root Extract Produced by Ultrasound-Assisted Enzymatic Extraction: Marker Content, Contaminants and Conformity with MS 2409:2011
This version is not peer-reviewed. Submitted: 24 October 2026 You are already at the latest version Market surveys of Tongkat Ali (Eurycoma longifolia) products have repeatedly found heavy-metal contamination and inconsistent marker content, yet manufacturers rarely publish their own quality data.
Combined Enzyme- and Ultrasound-Assisted Extraction of Botanical Bioactives for Nutraceutical Ingredients: Mechanisms, Process Design, Scale-Up and Safety
This version is not peer-reviewed. Submitted: 22 October 2026 You are already at the latest version Ultrasound-assisted extraction is widely promoted as a green technology for botanical ingredients, but two recent studies expose its limits.
Does Turmeric Essential Oil Enhance Curcumin Bioavailability? A Critical Review of the Human Pharmacokinetic Evidence and Its Implications for Curcuma Nutraceuticals
This version is not peer-reviewed. Submitted: 24 October 2026 You are already at the latest version Reviews of Curcuma essential oils catalogue many biological activities of turmerones, and a recent review states that adding turmeric oil increases curcumin bioavailability 6.93- to 8.2-fold. This review appraises the human evidence behind that claim. Six human pharmacokinetic studies of curcumin formulations containing turmeric oil or turmerones were identified.
Black Ginger ( Kaempferia parviflora ) for Nutraceuticals: From Methoxyflavone Marker Standardisation to Pharmacokinetics and Human Evidence
This version is not peer-reviewed. Submitted: 23 October 2026 You are already at the latest version Black ginger (Kaempferia parviflora) rhizome extracts are marketed across Asia for physical performance, metabolic health and male sexual function, and randomised trials now support several of these uses. Existing reviews summarise pharmacology or pool clinical outcomes but do not ask whether the extracts tested are comparable.
Beyond Encapsulation Efficiency: Designing Spray-Dried Botanical Extract Powders for Storage Stability in Hot and Humid Markets
This version is not peer-reviewed. Submitted: 22 October 2026 You are already at the latest version Spray drying with carbohydrate, gum and protein wall materials is the dominant route for converting botanical extracts into powders for supplements and functional foods. Most studies, and recent reviews of wall materials, judge success by encapsulation yield, encapsulation efficiency and particle morphology measured immediately after drying.
Postbiotic–Botanical Co-Formulations for Nutraceutical Powders: Interaction Mechanisms, Processing Design, Characterisation and Evidence Gaps
This version is not peer-reviewed. Submitted: 21 October 2026 You are already at the latest version Postbiotics, defined as preparations of inanimate microorganisms and/or their components that confer a health benefit on the host, are increasingly combined with botanical extracts in dried nutraceutical products. Recent reviews have addressed postbiotic definitions, production, food biopreservation and gut–brain effects, but have explicitly left nutraceutical co-formulations outside their scope.
Lipid-Based Nanocarriers for Oral Nutraceutical Delivery: Absorption Mechanisms, Manufacturing Routes and a Critical Appraisal of the Human Pharmacokinetic Evidence
This version is not peer-reviewed. Submitted: 21 October 2026 You are already at the latest version Many widely used nutraceuticals, including curcuminoids, polyphenols, carotenoids, coenzyme Q10 and labile vitamins, reach the systemic circulation poorly after oral intake because of low solubility, gastrointestinal degradation, efflux and presystemic conjugation. Lipid-based nanocarriers have become the leading commercial solution.
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