Kuan Cheok Lei

Abstract Merkel cell carcinoma (MCC) is an aggressive skin cancer with neuroendocrine differentiation marked by high cellular plasticity, often manifesting as rapid therapy resistance. Although the cell-of-origin is presumed to be epithelial, epidermal localization of MCC is rarely observed, largely because in situ MCC is typically an incidental finding. Nevertheless, a subset of MCC tumors exhibits epidermotropism, wherein tumor cells are present in the epidermis.

DGE Differential gene expression LTA large T antigen panTA-knockdown pan-T antigen knockdown scRNA-seq single-cell RNA sequencing shRNA short-hairpin RNA STA small T antigen TA T antigen UMI unique molecular identifier 1 INTRODUCTION Merkel cell polyomavirus (MCPyV; taxonomically classified in family Polyomaviridae, genus Alphapolyomavirus, species Human polyomavirus 5) is to date the only polyomavirus known to have a clear association with carcinogenesis in humans, i.e., Merkel cell...