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Kühlwein Julia

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Articles

High Agreement Across Laboratories Between Different Alpha‐Synuclein Seed Amplification Protocols

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By Stefan Brauer, Maximilian Weber, Christian Deuschle, Kühlwein Julia
| Wiley Online Library Verified
1 Introduction The deposition of pathologically aggregated forms of alpha-synuclein (aSYN) as intracellular inclusions is a central component in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders, collectively called synucleinopathies. Seed amplification assays (SAA) have been developed to detect minute amounts of “seeding competent” species of aSYN in cerebrospinal fluid (CSF), brain extracts, and other biomatrices [1-4] of patients with synucleinopathies.
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