Kuldeep Ram Tripathi

1 Introduction Legumes (family Fabaceae) play an important role in global food security, crop diversification and ecosystem sustainability (Stagnari et al. 2017). They also provide many other ecosystem services like atmospheric nitrogen (N) fixation and allow colonisation of arbuscular mycorrhizal fungi, which boost nutrient uptake and water supply in host plants (Ditzler et al. 2021).

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description pce15671-sup-0001-Fig_S1.TIF821.5 KB Fig S1. pce15671-sup-0002-Fig_S2.TIF1.2 MB Fig S2. pce15671-sup-0003-Fig_S3.tif1.9 MB Fig S3. pce15671-sup-0004-Fig_S4.tif2.3 MB Fig S4. pce15671-sup-0005-S1_Phenotyping_data.xlsx25.7 KB S1 Phenotyping data. pce15671-sup-0006-S2_QTLs_Mapping.xlsx424.5 KB S2 QTLs Mapping. pce15671-sup-0007-S3_GWAS_results.xlsx24 KB S3 GWAS results.

Abstract APPE693Q transgenic mice develop aging-related learning deficits and accumulate endogenously generated nonfibrillar aggregates of Aβ (NFA-Aβ) and APP α-carboxy terminal fragments. The APPE693Q mutation disrupts amyloid fibril formation, and no plaques develop in these mice. In the current study, the aging-related accumulation of NFA-Aβ in APPE693Q mice was revealed by A11 immunohistochemistry and NFA-Aβ-detecting cyclic D,L-α-peptide-FITC microscopy.