Kumar T. Movellan on Muck Rack

Kumar T. Movellan

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Lipidic folding pathway of α-Synuclein via a toxic oligomer - Nature Communications

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By Hisham Mazal, Leif Antonschmidt, Kai Xue, Marianna Stampolaki, Stefan Becker Verified, Vahid Sandoghdar, Christian Griesinger, Kumar T. Movellan
| Nature Verified
Abstract Aggregation intermediates play a pivotal role in the assembly of amyloid fibrils, which are central to the pathogenesis of neurodegenerative diseases. The structures of filamentous intermediates and mature fibrils are now efficiently determined by single-particle cryo-electron microscopy. By contrast, smaller pre-fibrillar α-Synuclein (αS) oligomers, crucial for initiating amyloidogenesis, remain largely uncharacterized.
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