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Kumba Seddu

As seen in: BioRxiv
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Articles

Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice

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By Santosh Dhakal, Han-Sol Park, Kumba Seddu, John Lee
| BioRxiv
Abstract Adult females of reproductive ages develop greater antibody responses to inactivated influenza vaccine (IIV) than males. How sex, age, and sex steroid changes impact B cells and durability of IIV-induced immunity and protection over 4-months post-vaccination (mpv) was analyzed.
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The interweaved signatures of common-gamma-chain cytokines across immunologic lineages

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By Tamara Salloum, Alev Baysoy, Kumba Seddu
| rupress.org
“γc” cytokines are a family whose receptors share a “common-gamma-chain” signaling moiety, and play central roles in differentiation, homeostasis, and communications of all immunocyte lineages. As a resource to better understand their range and specificity of action, we profiled by RNAseq the immediate-early responses to the main γc cytokines across all immunocyte lineages.
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