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Kundhanathan Ramesh on Muck Rack

Kundhanathan Ramesh

As seen in: BioRxiv
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Articles

Network toxicology focused investigation on the impacts of inorganic arsenic and cadmium on human and ecosystem health

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By Nikhil Chivukula, Shreyes Madgaonkar, Kundhanathan Ramesh, Swetha Mangot
| BioRxiv
Abstract Heavy metals like arsenic and cadmium are persistent environmental pollutants that pose serious health risks to humans and ecosystems due to their toxicity, bioaccumulation potential, and frequent presence in consumer products. Network toxicology offers a holistic in silico framework to elucidate the complex biological mechanisms of toxicity, thereby supporting New Approach Methodologies (NAMs) for toxicity assessment.
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Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

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By Ajaya Kumar Sahoo, Nikhil Chivukula, Shreyes Madgaonkar, Kundhanathan Ramesh
| BioRxiv
Abstract Plastics are widespread pollutants found in atmospheric, terrestrial and aquatic ecosystems due to their extensive usage and environmental persistence. Plastic additives, that are utilized to achieve specific functionality in plastics, leach into the environment upon plastic degradation and pose considerable risk to ecological and human health.
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An integrative data-centric approach to derivation and characterization of an adverse outcome pathway network for cadmium-induced toxicity

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By Ajaya Kumar Sahoo, Nikhil Chivukula, Kundhanathan Ramesh, Jasmine Singha
| BioRxiv
Abstract Cadmium is a prominent toxic heavy metal that contaminates both terrestrial and aquatic environments. Owing to its high biological half-life and low excretion rates, cadmium causes a variety of adverse biological outcomes. Adverse outcome pathway (AOP) networks were envisioned to systematically capture toxicological information to enable risk assessment and chemical regulation.
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