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Kunying Chen

As seen in: Cell Reports Medicine
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Articles

Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML

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By Yue Huang, Peifang Xiao, Lei Qin, Li Gao, Yang Zhao, Jingru Sui, Wenting Hu, Lei Zhou, Nan Sophia Han, Xuan Lv, Yu Liu, Shuhong Shen, Omar Abdel-Wahab Verified, Shaoyan Hu, Zhaoqi Liu, Qianfei Wang, Kunying Chen, Hanhong Lin
| Cell Reports Medicine Verified
Keywords pediatric acute myeloid leukemia therapy resistance splicing dysregulation U2AF2 downregulation PRMT enzymes Introduction The overall survival (OS) in pediatric patients with acute myeloid leukemia (AML) has been over 65%.1 However, 30% of patients are refractory to frontline treatment or suffer relapses, which are associated with an extremely poor prognosis.1,2 While some genetic variations, including somatic mutations on FLT3-ITD, WT1, and KIT, have been recognized as critical...
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