Kurt Yun Mou

Keywords bacterial therapy combinational cancer therapy leaky probiotic chimeric protein oncolytic toxins immune checkpoint inhibitors anticancer immunity Introduction Combinatorial therapies are a widely employed strategy against the complex and evolving oncogenic mechanisms of solid tumors.1 Multidrug synergism has demonstrated effectiveness in enhancing tumor suppression, preventing drug resistance development, overcoming the immune suppressive effect of tumor microenvironment, and...

Abstract Inflammatory bowel disease is a lifelong disorder that involves chronic inflammation in the small and large intestines. Current therapies, including aminosalicylates, corticosteroids, and anti-inflammatory biologics, can only alleviate the symptoms and often cause adverse effects with long-term usage. Engineered probiotics provide an alternative approach to treat inflammatory bowel disease in a self-renewable and local delivery fashion.