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Kwong-Man Ng

As seen in: Nature, MDPI
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Articles

IJMS | Free Full-Text | Isogenic Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes Reveal Activation of Wnt Signaling Pathways Underlying Intrinsic Cardiac Abnormalities in Rett Syndrome

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By Kwong-Man Ng, Qianqian Ding, Yiu-Lam Tse, Oscar Hou-In Chou
| MDPI
Open AccessArticle by Kwong-Man Ng 1,2, Qianqian Ding 3, Yiu-Lam Tse 1, Oscar Hou-In Chou 1, Wing-Hon Lai 1, Ka-Wing Au 1, Yee-Man Lau 1, Yue Ji 4, Chung-Wah Siu 1, Clara Sze-Man Tang 4,5, Alan Colman 6, Suk-Ying Tsang 3,7,8 and Hung-Fat Tse 2,9,10,* 1 Cardiology Division, Department of Medicine, Li Ka-Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China 2 Center for Translational Stem Cell Biology, Hong Kong SAR, China 3 School of Life Sciences, The Chinese University...
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Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes

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By Kwong-Man Ng, Yee-Man Lau, Vidhu Dhandhania, Zhu-Jun Cai
| Nature Verified
To recreate the diabetogenic environment, hiPSC (Line KS1)-derived cardiomyocytes were exposed to a high glucose (HG) environment by supplementing standard culture medium with 22 mM glucose for 14 days (Fig. 2A). Figure 2B shows the immunofluorescence staining of cardiomyocytes with normal glucose (NG) (5.5 mM) and HG culture medium. HG-treated cardiomyocytes were 5-fold larger than NG-treated cardiomyocytes (mean cell size: 67,163 ± 4,370 µm2 vs.
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