Kyeong Jin Lee on Muck Rack

Kyeong Jin Lee

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Pharmabiotics, Phocaeicola dorei , ameliorates cholestatic liver fibrosis by alleviating macrophage efferocytosis of neutrophils

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By Sang Yoon, Dong-Hoon Yang, Dong Joon Kim, Ki Tae Suk, Jung A Eom, Ji Ye Hyun, Goo Hyun Kwon, Sung-Min Won, Kyeong Jin Lee
| Nature Verified
Abstract Phocaeicola dorei has been reported to ameliorate metabolic diseases. Its role in liver fibrosis remains unclear. We evaluated the hepatoprotective effect of P. dorei in liver fibrosis. Fecal samples were collected from healthy controls and patients (n = 285) to assess the clinical relevance of P. dorei. In male mice models (3,5-diethoxycarbonyl-1.4-dihydrocollidine [DDC] diet), P. dorei (109 CFU/g twice/week) was orally administered.
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