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Kyle W. Barstch on Muck Rack

Kyle W. Barstch

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Articles

Systematic multi-omic deconvolution of the clinical heterogeneity of Down syndrome

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By Micah Donovan, Srija Chillamcherla, Belinda A. Enriquez Estrada, Kayleigh Worek, Zenitha Sundararajan, Kyle W. Barstch, Kelly Sullivan, Matthew Galbraith, Angela L. Rachubinski, Joaquin M. Espinosa
| Nature Verified
Abstract Persons with Down syndrome, the genetic condition caused by trisomy 21, are at high risk of developing various co-occurring conditions affecting all major organ systems. Recent multi-omic studies have revealed the profound impacts of trisomy 21 on human biology, including strong effects on the transcriptome, proteome, metabolome, and immunome. However, it is unclear whether these changes are conserved effects of trisomy 21 versus effects associated with specific co-occurring conditions.
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