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Kyong Tkhe Fam on Muck Rack

Kyong Tkhe Fam

As seen in: Nature, Royal Society of Chemistry, BioRxiv, eLife
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Articles

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

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By Kyong Tkhe Fam, Pavan Kumar Chodisetti, Zifei Wang
| BioRxiv
Abstract Vancomycin-resistant Enterococcus faecium (VREfm) is a leading cause of healthcare-associated infections globally and demands new approaches for treatment. Here we show that genetic and pharmacological inactivation of a highly conserved NlpC/P60 peptidoglycan hydrolase, secreted antigen A (SagA), enhanced vancomycin susceptibility of VREfm ex vivo and in vivo. Notably, genetic deletion of sagA impaired VREfm peptidoglycan remodeling, growth and increased the activity of vancomycin.
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Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor therapy

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By Steven Klupt, Kyong Tkhe Fam, Xing Zhang, Pavan Kumar Chodisetti
| eLife
eLife assessment The authors build upon prior data implicating the secreted peptidoglycan hydrolase SagA produced by Enterococcus faecium in immunotherapy. Leveraging new strains with sagA deletion/complementation constructs, the investigators reveal that sagA is non-essential, with sagA deletion leading to a marked growth defect due to impaired cell division, and sagA being necessary for the immunogenic and anti-tumor effects of E. faecium.
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Photoactivatable Plasma Membrane Probe Through Self-Triggered Photooxidation Cascade for Live Super-Resolution Microscopy

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By Sonia Pfister, Kyong Tkhe Fam, Mayeul Collot, Valentine Le Berruyer
| BioRxiv
Abstract Super-resolution imaging based on the localization of single emitters requires a spatio-temporal control of the ON and OFF state. To this end, photoactivatable fluorophores are adapted as they can be turned on upon light irradiation. Here we present a concept called Self-Triggered Photooxidation Cascade (STPC) based on the photooxidation of a plasma membrane targeted leuco-rhodamine (LRhod-PM), a non-fluorescent reduced form of a rhodamine probe.
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