Kyra Sohns

Loading metrics Open Access Peer-reviewed Research Article Citation: Sohns K, Kostenko A, Behrendt M, Schmelz M, Rukwied R, Carr R (2024) Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers. PLoS ONE 19(8): e0307668.

Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli suggest longer chronaxies. We therefore set out to optimize C-fiber stimulation based on recordings of single C-nociceptors in-vivo and C-fiber compound-action-potentials (C-CAP) ex-vivo using half-sine shaped stimuli of durations between 1 and 250ms.