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Lab. Molecular Mechanisms

As seen in: Journal of Translational Medicine
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Articles

Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB - Journal of Translational Medicine

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By Anna Rita, Lab. Molecular Mechanisms, Nucleic Acid Sensing, Biotechnology “L. Spallanzani”, Cristina Belgiovine, Elisabeth Digifico, Marco Erreni, Laura Mannarino, Fabio Grizzi, Fabio Pasqualini, Camilla Recordati, Luca Bertola, Paolo Andrea Zucali, Alberto Mantovani, Anna Rita Putignano, Sonia Valentino, Daniela Pistillo, Valentina Paleari
| Journal of Translational Medicine Verified
Materials and methods Tumor samples were obtained from 28 patients with pathologically confirmed pleural malignant mesothelioma (MPM) admitted at the IRCCS Humanitas Research Hospital (Rozzano, Milano, Italy). Biological samples were collected before start of therapy and immediately frozen or formalin-fixed and stored in the Institutional Biobank. Plasma samples were collected from 72 chemo-naive MPM patients admitted to Humanitas Hospital.
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Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB - Journal of Translational Medicine

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By Anna Rita, Biotechnology “L. Spallanzani”, Lab. Molecular Mechanisms, Nucleic Acid Sensing
| link.springer.com
Abstract Tumor-Associated Macrophages (TAMs) are the main immune component of the tumor stroma with heterogeneous functional activities, predominantly suppressing the immune response and promoting tumor progression, also via secretion of different factors. Among these, GPNMB (Glycoprotein non-metastatic B) is usually associated with disease progression in several tumor types.
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