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Laboratori de Càlcul Numeric

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Dynamics of supracellular keratin bundling and nuclear uncaging in stretched epithelia

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By Facultat de Medicina, Laboratori de Càlcul Numeric
| mtr.cool
Abstract There is broad consensus that intermediate filaments, such as keratin, play a key role in protecting cells and tissues from large deformations. However, little is known about how they fulfil this function. Here we show that epithelial cells slowly adapt to stretching through a coupling of a star-bundling transition of keratin filaments with the escape of the nucleus from its keratin cage.
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