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Laetitia Maroc

As seen in: BioRxiv
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Articles by Laetitia Maroc

A role for the putative error-prone polymerase REV1 in DNA damage and antifungal drug resistance in Candida albicans

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By Desiree Francis, Laetitia Maroc, Michelle R Agyare-Tabbi, Deeva Uthayakumar
| BioRxiv
Abstract Antimicrobial-induced DNA damage, and subsequent repair via upregulation of DNA repair factors, including error-prone translesion polymerases, can lead to the increased accumulation of mutations in the microbial genome, and ultimately increased risk of acquired mutations associated with antimicrobial resistance. While this phenotype is well described in bacterial species, it is less thoroughly investigated amongst microbial fungi.
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Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces glabrata via a novel CRISPR activation system

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By Rebecca Shapiro, Laetitia Maroc, Hajer Shaker
| BioRxiv
Abstract The overexpression of genes frequently arises in Nakeseomyces (formerly Candida) glabrata via gain-of-function mutations, gene duplication or aneuploidies, with important consequences on pathogenesis traits and antifungal drug resistance. This highlights the need to develop specific genetic tools to mimic and study genetic amplification in this important fungal pathogen. Here, we report the development, validation, and applications of the first CRISPR activation (CRISPRa) system in N.
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