Laijian Sui

1 Introduction Endocrine cancers comprise a diverse group of malignancies arising from hormone-producing tissues or hormone-dependent cells, which are typically divided into classical endocrine gland cancers, neuroendocrine tumors (NETs), and endocrine-dependent cancers (1). Among them, thyroid cancer is the most prevalent endocrine malignancies representing over 90%. Its global incidence is rising steadily, attributing to improved screening and diagnostic awareness (2, 3).

1 Introduction Osteosarcoma is a malignant tumor arising from mesenchymal tissues and displays a bimodal age distribution: the first peak occurs between ages 10 and 14, whereas the second peak appears after age 60 (1). The pathogenesis of osteosarcoma primarily involves mutations or inactivation of tumor suppressor genes, particularly TP53, and overexpression of oncogenes such as MDM2 (mouse double minute 2 protein) (2).

Supporting Information Filename Description acr25343-sup-0001-Disclosureform.pdfPDF document, 381.5 KB Disclosure Form acr25343-sup-0002-FigureS1.docWord document, 70.5 KB Figure S1. Meta analysis from atorvastatin to knee Osteoarthritis acr25343-sup-0003-FigureS2.docWord document, 266.5 KB Figure S2. Funnel plot of the causal relationships between statins and Osteoarthritis.