Laina Hall on Muck Rack

Laina Hall

As seen in: Nature, Cell Reports Medicine
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Articles

Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci

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By William S. Henriques, Laina Hall, Colin C. Gauvin, Jarrett Bowman
| biorxiv.org
Abstract Cas1 and Cas2 are the hallmark proteins of prokaryotic adaptive immunity. However, these two proteins are often fused to other proteins and the functional association of these fusions often remain poorly understood. Here we purify Cas1 and the Cas2/3 fusion protein from Pseudomonas aeruginosa. We determine multiple structures of the Cas1-2/3 complex at distinct stages of CRISPR adaptation.
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Transcriptional diversification in a human-adapting zoonotic pathogen drives niche-specific evolution - Nature Communications

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By Soma Ghosh, Laina Hall, Pavel Khil
| Nature Verified
Abstract Bacterial pathogens can undergo striking adaptive evolutionary change in the context of infection, driven by selection forces associated with host defenses and antibiotic treatment. In this work, we analyze the transcriptional landscape associated with adaptation in an emerging zoonotic pathogen, Bordetella hinzii, as it evolved during a 45-month infection in an IL12Rβ1-deficient immunocompromised host.
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Author Correction: A map of the rubisco biochemical landscape - Nature

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By Noam Prywes, Naiya R Phillips, Luke M Oltrogge, Sebastian Lindner, Leah J. Taylor-Kearney, Hana Chang, Renee Wang, Laina Hall, Daniel Bellieny-Rabelo, Hunter Nisonoff, Oliver Mueller-Cajar, Patrick M. Shih
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-024-08455-0 Published online 22 January 2025 In the version of the article initially published, the affiliations of Hana A. Chang (Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA) and Ron Milo (Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel) were incorrect and have now been amended in the HTML and PDF versions of the article.
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