Lalit Pramod Khare on Muck Rack

Lalit Pramod Khare

As seen in: Nature
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Articles

The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A - Nature Communications

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By Johanna Hultman, Vivian Morad, Eliane Tanner, Tristan M. G. Kenney, Zuzanna Pietras, Lalit Pramod Khare, Dean Derbyshire, Diana Resetca, Cheryl H Arrowsmith, Daniel Aili, Simon Ekström, Linda Z. Penn, Björn Wallner, Alexandra Ahlner, Maria Sunnerhagen
| Nature
Abstract The intrinsically disordered MYC proteins are master regulators of cellular growth and function, but when deregulated they become cancer drivers. MYC-protein interactions are key to oncogenesis, and while disrupting such interactions would be of significant therapeutic benefit, the intrinsically disordered properties of MYC have dramatically hampered their characterization.
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