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Lang-Jian Zhu

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Articles

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

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By Fan Wang, BGI Research Hangzhou, Ke-Yu Zhang, Lang-Jian Zhu
| Wiley Online Library Verified
1 Introduction Amyotrophic lateral sclerosis (ALS) is the most prevalent form of motor neuron diseases [1]. The primary pathological feature of ALS is the loss of motor neurons in the motor cortex, brainstem, and anterior horn of the spinal cord. This leads to progressive atrophy of innervated muscles and ultimately results in the loss of muscle control, speech ability, and respiratory function [2]. ALS progresses rapidly, with most patients succumbing within 3–5 years after symptom onset [3, 4].
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