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Articles by Lanlan Chen
A new method of landslide susceptibility assessment considering time-series InSAR surface deformation optimized non-landslide sample
ABSTRACT Due to the severe casualties and property losses caused by landslides, carrying out landslide susceptibility assessment (LSA) has important theoretical value and practical significance. However, affected by factors such as non-landslide sample selection and prediction model parameter setting, the results of landslide susceptibility evaluation have a certain deviation from the actual situation.
Hormone Replacement Therapy to Tackle MASLD Progression in Peri-Menopausal Women: Window of Opportunity or Call for Precision?
In this issue of Liver International, the study by Henney et al. [1] offers timely real-world evidence, suggesting that hormone replacement therapy (HRT) may mitigate both hepatic and cardiometabolic outcomes in perimenopausal women with metabolic dysfunction–associated steatotic liver disease (MASLD). In this context, we would like to revisit the mechanistic rationale, clinical implications, cautionary considerations and potential research questions surrounding HRT in MASLD.
Dubai vs. Abu Dhabi: Which City is Better for New Year's Eve?
When it comes to ringing in the New Year in style, Dubai and Abu Dhabi stand out as two of the most sought-after destinations in the UAE. Each city offers a unique flavor of celebration, making it a tough choice for travelers wondering where to spend their New Year's Eve. Whether you're after a high-octane party atmosphere or a more elegant, relaxed evening, both cities have something special to offer.
The Lipidomic Profile Discriminates Between MASLD and MetALD
Background: The recent consensus statement redefined steatotic liver diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) now represent distinct disease entities. However, biomarkers that differentiate MASLD and MetALD remain largely unknown. Aims: To identify lipidomic biomarkers with discriminatory potential for distinguishing MetALD from MASLD.
Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker
Abstract Accurate differentiation of benign and malignant breast tumors is paramount for establishing schemes of breast cancer treatment and prognosis. Here we report a near-infrared (NIR) fluorescence probe (YF-1) with the overexpressed cathepsin C (CTSC) in metastatic breast tumors as the detecting substrate. This probe allows accurate identification of malignant tumor tissue specimens among tumor tissue specimens with unknown properties in a blind study.
Attention to the misuse of Mendelian randomisation in medical research
Mendelian randomisation (MR) is a widely used method that employs genetic variants as instrumental variables (IVs, also referred to as genetic instruments below and they represent eligible genetic variants in MR) from genome-wide association studies (GWAS) to explore the causative relationship between putative risk factors (ie, exposures) and outcomes.1 According to a Web of Science literature search conducted at the end of 2024, the number of related publications has grown exponentially,...
The Lipidomic Profile Discriminates Between MASLD and MetALD
1 Introduction With the novel multi-society Delphi consensus statement, Metabolic dysfunction-associated steatotic liver disease (MASLD) and combined metabolic dysfunction-and alcohol-related steatotic liver disease (MetALD) are emerging as distinct subsets of steatotic liver disease (SLD) [1]. Both conditions are defined by lipid accumulation in the hepatocytes and by metabolic alterations that are driven by an interplay between genetics, lifestyle and environmental factors [2, 3].
Enhanced Barrier and Optical Properties of Inorganic Nano-Multilayers on PEN Substrate Through Hybrid Deposition
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Horticulturae | Free Full-Text | Comprehensive Analysis of Microbiomes and Metabolomics Reveals the Mechanism of Adaptation to Cadmium Stress in Rhizosphere Soil of Rhododendron decorum subsp. Diaprepes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Facile preparation of high-efficiency peroxidase mimics: Modulation catalytic microenvironment of LDH nanozymes through defect engineering induced by amino acids intercalation
Facile preparation of high-efficiency peroxidase mimics: Modulation catalytic microenvironment of LDH nanozymes through defect engineering induced by amino acids intercalation Nanozymes have gained much attention as the replacement of natural enzymes duo to their unique advantages. Two-dimensional layered double hydroxide (LDH) nanomaterials with high physicochemical plasticity are emerging as main forces for the construction of nanozymes.
Insights into Solvent Effects on Ni-BTC-Derived Ni@C Catalysts for the Hydrogenation of Phenolic Compounds
Download Hi-Res ImageDownload to MS-PowerPointCite This:Ind. Eng. Chem. Res. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Novel insights into causal effects of serum lipids and lipid-modifying targets on cholelithiasis
LC and WQ contributed equally. Contributors GL and LC proposed and designed the research. LC undertook data collection and performed the main data analysis. LC wrote the draft of the manuscript and ZF substantially revised the manuscript. WQ contributed to study design and data analysis in the revision. XS and WQ advised on the study design and revised the manuscript. MG supervised the statistical analysis and revised the manuscript. YZ and ML visualised the results and revised the manuscript.
Engineering Logic DNA Nanoprobes on Live Cell Membranes for Simultaneously Monitoring Extracellular pH and Precise Drug Delivery
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
New horizons of human genetics in digestive diseases
Genetics Digestive System It has been two decades since the initial assembly of the human Y chromosome sequence was first generated.1 However, this assembly remains incomplete. Recent groundbreaking developments, as reported in two publications from Nature, have now led to the complete decoding of the highly complex Y chromosome, promising a revolution in the field of human genetics.
Self-Promoted Ammonia Selectivity for the Electro-Reduction of Nitrogen on gt-C3N4 Supported Single Metal Catalysts: The Machine Learning Model and Physical Insights
Self-Promoted Ammonia Selectivity for the Electro-Reduction of Nitrogen on gt-C3N4 Supported Single Metal Catalysts: The Machine Learning Model and Physical Insights Selectivity toward ammonia is an important indicator of a good electrocatalyst for nitrogen reduction reaction (eNRR).
Two-dimensional conductive metal-organic frameworks as efficient electrocatalysts for oxygen evolution and reduction reactions
Two-dimensional conductive metal-organic frameworks as efficient electrocatalysts for oxygen evolution and reduction reactions Yanan Zhou, Li Sheng, Lanlan Chen, Qiquan Luo, Wenhui Zhao, Wenhua Zhang and Jinlong Yang Abstract It is vital to search for efficient and stable oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) electrocatalysts for the development of metal-air batteries.
The causal effects of inflammatory bowel disease on primary biliary cholangitis: A bidirectional two‐sample Mendelian randomization study
ORIGINAL ARTICLE Hongchen Zhang, Lanlan Chen and Zhongqi Fan contributed equally to the study. Handling Editor: Luca Valenti Abstract Background Observational studies have indicated that the incidence of primary biliary cholangitis (PBC) is higher in inflammatory bowel disease (IBD) patients than that in healthy people. However, whether the correlation is causal remains unclear.
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice - Nature Communications
Abstract The early phase lipid accumulation is essential for liver regeneration. However, whether this acute lipid accumulation can serve as signals to direct liver regeneration rather than simply providing building blocks for cell proliferation remains unclear. Through in vivo CRISPR screening, we identify MIER1 (mesoderm induction early response 1) as a key epigenetic regulator that bridges the acute lipid accumulation and cell cycle gene expression during liver regeneration in male animals.
Pharmacological agents for defatting livers by normothermic machine perfusion
Abstract Background Ex-vivo normothermic machine perfusion (NMP) preserves the liver metabolism at 37°C and has rapidly developed as a promising approach for assessing the viability and improving the performance of organs from expanded criteria donors, including fatty liver grafts. NMP is an effective method for defatting fatty livers when combined with pharmaceutical therapies. Pharmacological agents have been shown to facilitate liver defatting by NMP.
Plasmon Enhanced Catalysis-Driven Nanomotors with Autonomous Navigation for Deep Cancer Imaging and Enhanced Radiotherapy
Plasmon Enhanced Catalysis-Driven Nanomotors with Autonomous Navigation for Deep Cancer Imaging and Enhanced Radiotherapy Luntao Liu, Qingqing Li, Lanlan Chen, Lihong Song, Xueqiang Zhang, Hongqi Huo, Zhixin You, Ying Wu, Zongsheng Wu, Jiamin Ye, Qinrui Fu, Lichao Su, Xuan Zhang, Huanghao Yang and Jibin Song Abstract Radiosensitizers potentiate the radiotherapy effect while effectively reducing the damage to healthy tissues.
Nucleic acid-based molecular computation heads towards cellular applications
Nucleic acid-based molecular computation heads towards cellular applications Lanlan Chen, a Wanzhen Chen,a Guo Liu,a Jingying Li,b Chunhua Lu, a Juan Li,ac Weihong Tan *cd and Huanghao Yang *a Author affiliations * Corresponding authors a MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou...
Single Mo1(W1, Re1) Atoms Anchored in Pyrrolic-N3 Doped Graphene as Efficient Electrocatalysts for the Nitrogen Reduction Reaction
Single Mo1(W1, Re1) Atoms Anchored in Pyrrolic-N3 Doped Graphene as Efficient Electrocatalysts for the Nitrogen Reduction Reaction Nitrogen doped graphene supported single metal atoms are expected to achieve high nitrogen reduction reaction (NRR) performance via electroreduction process.
Single Atoms of Iron on MoS2 Nanosheets for N2 Electroreduction into Ammonia
Communication Hongyang Su Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Strongly-Coupled Quantum Matter Physics, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026 P. R. China These authors contributed equally to this work.
Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems
Labile heme (LH) is an important signaling molecule in virtually all organisms. However, specifically detecting LH remains an outstanding challenge. Herein, by learning from the bioactivation mechanism of artemisinin, we have developed the first LH-responsive small-molecule fluorescent probe, HNG, based on a 4-amino-1,8-naphthalimide (NG) fluorophore. HNG showed high selectivity for LH without interference from hemin, protein-interacting heme, and zinc protoporphyrin.
Frequent Daytime Napping is Detrimental to Human Health: A phenotype-wide Mendelian Randomization Study
Lanlan Chen, Aowen Tian, Zhipeng Liu, Miaoran Zhang, Xingchen Pan, Chang He, Wanqing Liu, View ORCID ProfilePeng Chen doi: https://doi.org/10.1101/2020.01.20.20017723 ABSTRACT Background It remains controversial whether daytime napping is beneficial for human health. Objective To examine the causal relationship between daytime napping and the risk for various human diseases. Design Phenotype-wide Mendelian randomization study.
Tumor-Acidity Activated Surface Charge Conversion of Two-Photon Fluorescent Nanoprobe for Enhanced Cellular Uptake and Targeted Imaging of Intracellular Hydrogen Peroxide
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Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging
Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies.
Engineering of a Near-infrared Fluorescent Probe for Real-time Simultaneous Visualization of Intracellular Hypoxia and the Induced Mitophagy
Mitophagy induced by hypoxia plays an important role in regulating cellular homeostasis through removing dysfunctional mitochondria in a lysosomal degradation pathway, which results in physiological changes of mitochodria, such as pH, polarity and viscosity. However, the lack of effective methods to image both hypoxic microenvironment and the resulted variable mitochondria limits visualization of hypoxia induced mitophagy.
Interface engineering of the Ni(OH)2-Ni3N nanoarray heterostructure for the alkaline hydrogen evolution reaction
It is highly attractive but challenging to design and develop noble-metal-free catalysts with outstanding electrocatalytic activity for the hydrogen evolution reaction (HER) in alkaline media. In this work, we demonstrate the development of Ni(OH) –Ni N nanoarrays on Ti mesh (Ni(OH) –Ni N/TM) as a three-dimensional (3D) HER catalyst in alkaline solutions.
Interface engineering of Ni(OH)2-Ni3N nanoarray heterostructure for alkaline hydrogen evolution reaction
It is highly attractive but challenging to design and develop noble-metal-free catalysts with outstanding electrocatalytic activity for the hydrogen evolution reaction (HER) in alkaline media. In this work, we demonstrate a development of Ni(OH)2-Ni3N nanoarray on Ti mesh (Ni(OH)2-Ni3N/TM) as the three-dimensional (3D) HER catalyst in alkaline solutions.
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