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Lanqing Ying on Muck Rack

Lanqing Ying

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Articles

The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function

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By Zhiling Kuang, Xueni Li, Zhichao Tang, Shasha Shi, Karoline A Lambert, Wenzheng Zhang, Joseph A. Giovinazzo, Wencheng Li, Jingxin Wang, Rui Zhao, Brian Kosmyna, Kerstin A. Effenberger, Jairo Sierra, Lanqing Ying, Scott J. Barraza, Christopher R. Trotta
| Nature Verified
Abstract Risdiplam and branaplam represent two classes of small-molecule splicing modulators that promote U1 snRNP recognition of weak non-canonical GA/GU-containing 5’ splice sites (ss). We demonstrate that branaplam enhances recognition of these 5’ ss by reconstituted U1 snRNP in vitro, and that this effect depends on the ZnF domain of U1C and Helix H of U1 snRNA, but not U1A or U1-70K.
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