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In this section, we provide representative results obtained following the ex utero electroporation of a control plasmid, or an experimental plasmid targeting a gene of interest, in the MGE of e13.5 mouse embryos followed by organotypic slice cultures incubated at 37 °C for 48 h (for time-lapse imaging) or 72 h (for fixation and immunohistochemical labeling) (see Figure 1B for schematic protocol).
IntroductionUbiquitinated cytoplasmic inclusions are a common pathological feature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). TDP-43 (encoded by TARDBP) has been known to be a major component of such inclusions (Arai et al., 2006; Neumann et al., 2006). TDP-43 is a nuclear RNA binding protein that redistributes from the nucleus to cytoplasm in affected neurons or glial cells (Arai et al., 2006; Neumann et al., 2006).
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