Largess Barua on Muck Rack

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Articles

Elucidating conformational alteration of human islet amyloid polypeptide by nonsynonymous substitution

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By Abul Bashar, Supti Paul, Largess Barua, Nayan Dash
| biorxiv.org
Abstract Islet amyloid polypeptide (IAPP) is a peptide hormone that serves multiple essential functions, including metabolism and regulating gastric emptying and satiation through amylin receptors. However, mutations in the IAPP, notably in the amyloidogenic segment (20-29 amino acid residues), cause its aggregation and amyloid formation, which leads to β-cell toxicity and death in type 2 diabetes mellitus (T2DM) and protein misfolding disorders (PMDs).
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