Lariza Rento on Muck Rack

Lariza Rento

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Articles

Somatic genomic changes in single Alzheimer’s disease neurons - Nature

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By Michael Miller, August Yue Huang, Eduardo A Maury, Steven Ryu, Heather Ames, Bradley T. Hyman, Michael A. Lodato, Christopher Walsh, Samantha L. Kirkham, Jennifer S. Ziegenfuss, Lariza Rento
| Nature Verified
Abstract Dementia in Alzheimer’s disease progresses alongside neurodegeneration1,2,3,4, but the specific events that cause neuronal dysfunction and death remain poorly understood. During normal ageing, neurons progressively accumulate somatic mutations5 at rates similar to those of dividing cells6,7 which suggests that genetic factors, environmental exposures or disease states might influence this accumulation5.
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