Larrisa Hoell on Muck Rack

Larrisa Hoell

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Articles

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities

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By Sadhna Phanse, Hiroyuki Aoki, Kirsten Broderick, Qingzhou Zhang, Ines Castro, Sakib Hossain, Tatiana Saccon, Mohamed Taha Moutaoufik, Shahreen Amin, Zoran Minic, Yury Bykov, Noga Preminger, Jamie Snider, Ashkan Golshani, Igor Stagljar, Catherine Clarke, Maya Schuldiner, Mohan Babu, Matthew Jessulat, Noelle Alexa Novales, Thomson Patrick Joseph, Larrisa Hoell, Sahily Gonzalez Crespo, Jose R. Rodriguez-Medina
| Nature Verified
Abstract Mitochondria are essential organelles whose functions depend on coordinated multiprotein complexes, yet their composition and organization remain incomplete. Here, we present a large-scale map of mitochondrial protein complexes by integrating affinity purification of 740 endogenously GFP-tagged mitochondrial proteins with biochemical co-fractionation of mitochondrial extracts from yeast (Saccharomyces cerevisiae) grown under respiratory conditions.
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