Lars Erik Bartels
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COVID‐19 Vaccination Before Initiating Rituximab Treatment Induces Strong Serological Response in Autoimmune Rheumatic Disease, Reducing Post‐Pandemic Concerns About the Impact of Rituximab
INTRODUCTION Rituximab (RTX), a monoclonal antibody targeting CD20, acts as a potent B cell–depleting agent. It is a highly effective treatment option for various rheumatic diseases by selectively depleting CD20-positive B cells. Given its impact on humoral immunity, considerable concern has been emphasized regarding using RTX throughout the COVID-19 pandemic.
Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study
Discussion In this study, we found a discrete increased risk of testing positive for SARS-CoV-2 and being vaccinated in patients with IRD compared with the general population in Denmark. Patients with AAV, RA, SLE and SSC had a substantially higher risk of hospitalisation, severe COVID-19, need of assisted ventilation and death compared with the matched controls from the general population and patients with IRD in general.
Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study
http://orcid.org/0000-0002-2639-3055Annemarie Lyng Lyng Svensson1, Hanne-Dorthe Emborg2, http://orcid.org/0000-0002-9101-1076Lars Erik Bartels3, http://orcid.org/0000-0003-0426-4962Torkell Ellingsen4, Thomas Adelsten5, René Cordtz6,7, Lene Dreyer8,9, Niels Obel2,10 1Department of Rheumatology, Center for Rheumatology and Spine Diseases, Rigshospitalet HovedOrtoCentret, Kobenhavn, Denmark 2Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Kobenhavn, Denmark...
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