LaShalle King on Muck Rack

LaShalle King

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Articles

Dynamic uterine microenvironment drives endometrial adenocarcinoma carcinogenesis and progression

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By Shiwei Yin, Brenna Hobson, Katelyn Andersen, John Coté, Robin Farias-Eisner, Jun Xia, Yusi Fu, Lesley B. Conrad, Bingru Feng, LaShalle King
| Nature Verified
Abstract Endometrial cancer (EC) development is driven by the interaction between the tumor and the microenvironment. However, the immune microenvironment dynamics during this process are not clear. Here, we applied single-cell RNA sequencing (scRNA-seq) to uterine blood samples collected at hysterectomy from 15 individuals encompassing four groups—benign controls, endometrial intraepithelial neoplasia (EIN), the transition from EIN to carcinoma, and EC.
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