Laura Barberi

1 Introduction The loss of mass and strength, referred to as sarcopenia, is a highly prevalent condition in patients with chronic liver disease (CLD), associated with significant clinical complications, poor prognosis and high mortality [1, 2]. Severe sarcopenia occurs in approximately 60% of patients with alcoholic liver disease (ALD), the most common cause of liver disease globally [3].

AbstractSkeletal muscle myopathy is universal in cirrhotic patients, however, little is known about the main mechanisms involved. The study aims to investigate skeletal muscle morphological, histological, and functional modifications in experimental models of cirrhosis and the principal molecular pathways responsible for skeletal muscle myopathy. Cirrhosis was induced by bile duct ligation (BDL) and carbon tetrachloride (CCl4) administration in mice.

IntroductionAge?related sarcopenia is a syndrome characterized by a progressive loss of muscle mass and strength that greatly impacts on mobility and mortality in elderly persons (Hughes et al. 2001; Aagaard et al. 2010; Cruz?Jentoft et al. 2010; Mitchell et al. 2012; Bijlsma et al. 2013; Miljkovic et al. 2015).