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Laura Cecilia Zelarayan on Muck Rack

Laura Cecilia Zelarayan

As seen in: Stem Cell Reports
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Articles

Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling

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By Rosa Kim, Eric Schoger, Chloe D Morsink, Jesper Hjortnaes, Diederik W.D. Kuster, Reinier A. Boon, Qianliang Yuan, Devin Verbueken, Rafeeh Dinani, Shamim Amiri Simkooei, Luuk J.M. Kemna, Laura Cecilia Zelarayan, Jan W. Buikema
| Stem Cell Reports Verified
Keywords hiPSC-CMs iPSC cardiomyocytes CHIR99021 Wnt insulin proliferation maturation FOXO TCF Introduction The lack of understanding about true regeneration of the human heart is reflected in the current medical therapies for heart failure that do not aim to cure the underlying deficit of functional cardiomyocytes (Galdos et al., 2017; Lazar et al., 2017; Ouwerkerk et al., 2023).
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