Laura K. Dunbar

Abbreviations aGLP‐1 active glucagon‐like peptide‐1 AUC area under the curve DPP‐4 dipeptidyl peptidase 4 EDTA ethylenediaminetetraacetic acid EIA enteroinsular axis GIP glucose‐dependent insulinotropic polypeptide GLP‐1 glucagon‐like peptide‐1 IgG immunoglobulin G IVGT IV glucose test OGT oral glucose test OLT oral lactose test 1 INTRODUCTION The enteroinsular axis (EIA) comprises intestinal factors (incretins) that stimulate insulin release after PO ingestion of nutrients.

Abstract Background The enteroinsular axis (EIA) comprises intestinal factors (incretins) that stimulate insulin release after PO ingestion of nutrients. Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are the main incretins. The EIA has not been investigated in healthy neonatal foals but should be important because energy demands are high in healthy foals and dysregulation is frequent in sick foals.