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SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis
Editor’s summary Gray matter lesions are associated with motor and cognitive deficits in people with multiple sclerosis (PwMS) but are challenging to detect by magnetic resonance imaging (MRI), the gold standard used for detecting white matter lesions. To investigate whether positron emission tomography (PET) imaging of synaptic vesicle protein 2A (SV2A) could be used to detect gray matter lesions, Ullrich Gavilanes et al.
Neuronal and oligodendroglial but not astroglial tau translates to in vivo tau-PET signals in primary tauopathies
Abstract Tau-PET receives growing interest as an imaging biomarker for the 4-repeat tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau-PET signals is still unclear. Therefore, we conducted a longitudinal [18F]PI-2620 PET/MRI study in a 4-repeat-tau mouse model (PS19) and found elevated [18F]PI-2620 PET signal in the presence of high neuronal tau.
Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
NLA and MB are members of the Neuroimaging Committee of the EANM. JCT received research grants from Novocure and Munich Surgical Imaging and a speaker honorarium from Seagen. NLA received funding from Novocure. MB received speaker honoraria from Roche, GE healthcare and Life Molecular Imaging and is an advisor of Life Molecular Imaging. VCR received speaker honoraria from Novocure.
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