Laure-Elise Pillet on Muck Rack

Laure-Elise Pillet

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Astroglial deficiency for oligophrenin-1 contributes to intellectual disability

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By Noémie Cresto, Pascal Ezan, David Mazaud, Laure-Elise Pillet
| biorxiv.org
Abstract Neurodevelopmental disorders, including X-linked intellectual disability, autism spectrum disorder or schizophrenia, can result from the mutation of oligophrenin-1 (Ophn1), encoding a Rho-GTPase-activating protein. Ophn1 regulates synaptic development and function, in part via cytoskeleton reorganization, and is expressed in both neurons and astrocytes.
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