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Laure Gambardella on Muck Rack

Laure Gambardella

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Articles

Dynamics of human cardiogenesis and its disruption in trisomy 21

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By James Cranley, Kazumasa Kanemaru, Semih Bayraktar, Vincent R Knight-Schrijver, Rebecca Hulbert, Eva Lana-Elola, Rifdat Aoidi, Jan Patrick Pett, Anna Wilbrey-Clark, Krzysztof Polanski, Monika Dabrowska, Ilaria Mulas, Harriet Johnson, Noémie Combémorel, Yizhou Yu, Jack Palmer, Woochan Lee, Jore Van Wauwe, John-Poul Ng-Blichfeldt, Laura Richardson, Claudia I. Semprich, Rakeshlal Kapuge, Xiaoling He, Siew Yen Ho, Nadav Yayon, Liz Tuck, Kenny Roberts, Hongorzul Davaapil, Laure Gambardella, Anna Philpott, Minal Patel, Richard Tyser, Andreia Sofia Bernardo, Victor L. J. Tybulewicz, Sanjay Sinha, Sarah A Teichmann, Shani Perera
| Nature Verified
Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches1. Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a context-aware, resolution-agnostic niche classification tool (TissueTypist). Applying high-resolution spatial profiling to the developing sinoatrial node, we resolve three pacemaker cell subtypes arrayed along a linear axis.
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