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Laurent Adonis Bekale on Muck Rack

Laurent Adonis Bekale

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Articles

A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation

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By Kelly Khomtchouk, Anping Xia, Ali Kouhi, Laurent Adonis Bekale
| Science Magazine Verified
Abstract Chronic suppurative otitis media (CSOM) is a neglected pediatric disease affecting 330 million worldwide for which no new drugs have been introduced for over a decade. We developed a mouse model with utility in preclinical drug evaluation and antimicrobial discovery. Our model used immune-competent mice, tympanic membrane perforation and inoculation with luminescent Pseudomonas aeruginosa that enabled bacterial abundance tracking in real-time for 100 days.
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