Laurentijn Tilleman

Nunez, S. et al. The human thymus perivascular space is a functional niche for viral-specific plasma cells. Sci. Immunol. 1, eaah4447 (2016). Article Google Scholar Park, J. E. et al. A cell atlas of human thymic development defines T cell repertoire formation. Science 367, eaay3224 (2020). Article CAS Google Scholar Watanabe, N. et al. Hassall’s corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436, 1181–1185 (2005). Article CAS Google Scholar Lavaert, M. et al.

In recent years, the number of published tumor-related sequences has increased remarkably, leading to an accelerated understanding of the genomic profile of different cancer tissues [1–3]. The exponentially expanding literature about cancer pharmacogenetics has been aggregated into accessible knowledgebases []. However, tumor sequencing is required to implement this knowledge in clinical practice and to allow a more personalized therapy for the patient [13,14].

Abstract Short Tandem Repeat (STR-) and Single Nucleotide Polymorphism (SNP-) genotyping have been extensively studied within forensic kinship analysis. Nevertheless, no results have been reported on kinship analysis after whole genome amplification (WGA) of single cells. This WGA step is a necessary procedure in several applications, such as cell-based non-invasive prenatal testing (cbNIPT) and pre-implantation genetic diagnosis (PGD).