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Laurien J. Zeverijn on Muck Rack

Laurien J. Zeverijn

As seen in: Wiley Online Library, Cell Reports Medicine, The Lancet
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Articles

Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer

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By Maartje Witsen, Karlijn Verkerk, Laurien J. Zeverijn, Krijn K. Dijkstra, Leila Akkari, Emile E. Voest, Miguel Parra-Martinez, Marit Steur
| Cell Reports Medicine Verified
Clinical data analysis The Drug Rediscovery Protocol (DRUP) is an ongoing prospective, multicenter, nonrandomized clinical trial in which patients with advanced or metastatic solid tumors who have exhausted all standard-of-care options are treated based on their tumor molecular profile with approved targeted therapies or immunotherapies outside their registered indication.26 For the clinical analyses, we included patients with MMR-d cancers treated with PD-(L)1 blockade from three completed...
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Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

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By Niven Mehra, Laurien J. Zeverijn, Birgit S Geurts, Karlijn Verkerk
| Wiley Online Library Verified
AML acute myeloid leukemia BOR best overall response CB clinical benefit CBR clinical benefit rate CHORD Classifier of Homologous Recombination Deficiency CI confidence interval CR complete response CTCAEv4.03 Common Terminology Criteria for Adverse Events version 4.03 DoR duration of response DRUP Drug Rediscovery Protocol DSBs double-strand breaks ECOG Eastern Cooperative Oncology eCRF electronic case report form EMA European Medicines Agency FDA U.S. Food and Drug Administration GMI growth...
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Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy

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By Birgit S Geurts, Laurien J. Zeverijn, Louisa Hoes, Ilse AC Spiekman
| Wiley Online Library Verified
Supporting Information Filename Description path6279-sup-0001-TablesS1,S2.docxWord 2007 document , 22.8 KB Table S1. Average relative contribution of single-base substitution signatures associated with dMMR/MSI in WGS-based MSI tumors (n = 108) Table S2. Relative contribution of signatures associated with dMMR/MSI in WGS-based MSS tumors References 1, , , et al. Landscape of microsatellite instability across 39 cancer types. JCO Precis Oncol 2017; 2017: PO.17.00073. 2, , , et al.
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