Laxminath Tumburu on Muck Rack

Laxminath Tumburu

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Articles

Targeting ZNF410 as a potential β-hemoglobinopathy therapy

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By Laxminath Tumburu, Swee Lay Thein
| Nature Verified
The nucleosome remodeling and deacetylase (NuRD) complex is a chromatin modifier with a key role in the switch from fetal to adult hemoglobin. In a new study, Vinjamur et al. identify a fetal hemoglobin repressor, ZNF410, which does not directly bind the γ-globin promoter but acts through highly specific regulation of CHD4, a protein subunit of the NuRD complex, thus presenting a potential approach for therapeutic reactivation of fetal hemoglobin. Fig.
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HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts

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By Colleen Byrnes, Y. Terry Lee, Laxminath Tumburu, Antoinette Rabel
| PLOS
Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs (miRNAs) are highly regulated in erythroid cells during the fetal-to-adult developmental transition, and that targeting let-7 mediated the up-regulation of HbF to greater than 30% of the total globin levels in human adult cultured erythroblasts.
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