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Le-Ying Gao on Muck Rack

Le-Ying Gao

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Articles

Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders

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By Qian-Qian Wu, Hui Gao, Wei Peng, Nan Li, Le-Ying Gao, Hui-Yi Feng, Hao-Lin Liu
| Frontiers
Abstract Homeostatic imbalance of bile acids (BAs) is closely associated with the onset and progression of several liver diseases, including cholestasis, hepatic fibrosis, cirrhosis, hepatocellular carcinoma, and MASLD/MASH. In cholestasis, BAs imbalance induces cellular endoplasmic reticulum stress and mitochondrial dysfunction, which subsequently lead to hepatocellular and cholangiocellular death, exacerbating liver injury.
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