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Le Zhen

As seen in: Nature, SAGE Publishing, BioRxiv
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Articles by Le Zhen

α-KG conformationally stabilizes nuclear GLUD1-SNAIL complex to fuel trans-endothelial migration in metastasis

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By Jiawen Cui, Nuo Xu, Rongyu Cao, Ruqi Zhang, Ying Yu, Luyao Ao, Feiyi Wang, Qixing Gong, Le Zhen, Yantong Li, Qingqing Zhou, Yue Dang, Guangji Wang, Fang Zhou, Jiali Liu
| Nature Verified
Abstract Trans-endothelial migration (TEM) is a critical rate-limiting barrier in tumor metastasis, yet its mechanistic basis remains poorly defined. Here we show that α-ketoglutarate (α-KG) and its metabolic enzyme glutamate dehydrogenase 1 (GLUD1) constitute a pivotal regulatory axis governing this process.
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Soft, precision engineered porous, hydrogel scaffolds mechanically tailored toward applications in the central nervous system

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By Le Zhen, Ningjing Chen, Manjari Anant, Rebecca Darrow
| SAGE Publishing
Skip to main content Intended for healthcare professionals Restricted access Research article Get full access to this article View all access and purchase options for this article. References 1. Virani S, Alonso A, Benjamin E, et al. Heart disease and stroke statistics—2020 update: a report from the American Heart Association. Circulation 2020; 141: e139–e596. 2. Lasfargues JE, Custis D, Morrone F, et al. A model for estimating spinal cord injury prevalence in the United States.
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Immunomodulatory Porous Regenerative Scaffolds for in situ Vascular Engineering

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By Elina Quiroga, Sharon Creason, Ningjing Chen, Le Zhen
| BioRxiv
Abstract The 70-year quest for synthetic vascular graft (sVG) endothelialization has not led to completely healed endothelium in clinically used sVGs. In humans, healing is limited to the vicinity of anastomotic regions (pannus ingrowth) and does not reach the middle regions of sVGs. Here, we conducted proof-of-concept implantation of immunomodulatory porous regenerative scaffolds for in situ vascular engineering (IMPRESSIVE) as interposition grafts in sheep carotid arteries.
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