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Léa Barral on Muck Rack

Léa Barral

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Articles

Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance

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By Nicolas Lespinasse, Anna Bourgeois, Emmanuel Beillard, Pauline Peyrouze, Amine Belhabri, Yann Guillermin, Frédéric Mazurier, Meyling Cheok, Véronique Maguer-Satta, Sylvain Lefort, Léa Barral, Camila Martin Cardozo, Sandrine Jeanpierre, Katharina Rösel, Djohana Laurent, Marie-Charlotte Audry-Deschamps, Magalie Faivre
| Nature Verified
Abstract Despite extensive research and intensive use of chemotherapies in clinics, the 5-year overall survival of acute myeloid leukemia (AML) patients does not exceed 20%. The clonal expansion of leukemic blasts leads to modifications of the bone marrow physical properties, including increased extracellular matrix stiffening, upregulation of intramedullary pressure and reduction of the space available for cells.
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