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Articles

How should myelodysplastic neoplasms with isolated deletion 5q and TP53 multihit alterations be classified?

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By Maria Julia Montoro, Pamela Acha, Claudia Haferlach, Onyee Chan, Víctor Navarro Verified, Yasuo Kubota, Felicitas Schulz, Robert Briski, Najla Al Ali, Blanca Xicoy, Laura F. Palomo, Francesc Bosch, Manja Meggendorfer, Teresa Gonzalez, Andrés Jerez, Alessia Campagna, Valeria Santini, Teresa Bernal, Esperanza Such, Tariq Kewan, Carmelo Gurnari, Austin G. Kulasekararaj, Maria Teresa Voso, Mikkael Sekeres, Aref Al-Kali, Elisa Diral, Mara Memoli, Uwe Platzbecker, Amer M Zeidan, María Díez-Campelo, Guillermo Garcia-Manero, Daniel H. Wiseman, Matteo Della Porta, Ulrich Germing, Jaroslaw Maciejewski, Rami S. Komrokji, Francesc Solé, Torsten Haferlach, Pierre Fenaux, David Valcárcel, Felix López-Cadenas, Lea Naomi Eder, YuHung Wang, Beate Betz, Anne Sophie Platzbecker, Carla Zindel, Nicolas Díaz-Varela, Antonella Polini, Detlef Haase
| Nature Verified
Abstract Myelodysplastic neoplasms (MDS) with TP53 multihit alterations are associated with dismal outcomes. MDS with isolated del(5q) present favorable prognosis but is defined by the absence of TP53 multihit alterations. However, whether TP53 multihit alterations exert the same adverse impact in this genetic context remains uncertain.
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