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Lea Stefanie Meßmer

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Boosting the engraftment of subcutaneously transplanted pancreatic islets by nanofat

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By Selina Wrublewsky, Caroline Bickelmann, Cedric Wilden, Lea Stefanie Meßmer
| Wiley Online Library Verified
1 INTRODUCTION Subcutaneous islet transplantation is a preferential treatment option that may improve the quality of life for type 1 diabetes mellitus (T1DM) patients.1, 2 However, so far this therapeutic approach has not been widely used in clinical practice, which is mainly due to the poor vascularisation capacity of the subcutaneous space, resulting in ischaemia-induced cell death of transplanted islets.1, 2 Accordingly, the prompt restoration of the islet blood vessel network and, thus,...
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