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Leah WElls on Muck Rack

Leah WElls

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Articles by Leah WElls

Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis

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By Leah WElls, Aikta Sharma, Neil Marr, Rebecca Hansen, Janice Pereira, Toby Roe, Helen Roberts, Udo Oppermann, Paul Clarke Verified, Andrew Pitsillides, Scott Roberts, Jacob A. C. Keen
| Nature Verified
Abstract Chondrocyte hypertrophy is a key hallmark of osteoarthritis (OA) that drives a multitude of whole-joint disease processes. There are no approved disease-modifying pharmaceuticals in clinical use, emphasising the urgent need for innovative therapeutics. Screening of a focussed chemical library using a novel in vitro platform discovered that inhibition of CDK8/19 mediator kinases modulated chondrocyte behaviours with potential to limit OA hallmarks.
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Evaluation of Gemtuzumab Ozogamicin and Anthracycline Dosing for Favorable Risk Acute Myeloid Leukemia

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By Joseph F. Mort, David Brighton, Samantha DiBenedetto, Leah WElls
| Wiley Online Library Verified
Conflicts of Interest J.F.M., D.B., S.D., S.M.C., J.R., I.P., C.J., B.Y., R.M., M.P., K.W., D.R.R., M.K., and B.H. declare no conflict of interest. L.W.'s spouse is employed as a sales representative at AbbVie Pharmaceuticals within the immunology-dermatology division. H.W. works for an institution that receives a grant or contract from Schrodinger Inc. S.C.L. declares research funding from AbbVie, BMS, GSK, and Jazz Pharmaceuticals.
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