Paul Clarke on Muck Rack

Paul Clarke

Verified
Hull
As seen in: Iconic Media, British Journal of Cancer, Nature, Sunday Mirror, The Daily Mirror, Wiley Online Library, Daily Express, WIRED Magazine, Wales on Sunday, Western Mail, Irish Independent and
Group Sport Editor @NatWorldPub Previously sports content editor and reporter at Reach PLC.
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Articles

The Tsetlin Machine: A “Third Way” in QSAR Modeling Click to copy article link Article link copied!

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By Paul Clarke Verified, Ivan Čmelo, Runar Helin
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! The goal of Quantitative Structure Activity Relationship (QSAR) is to find statistically relevant patterns in data between chemical structures and their biological activity properties (active, inactive, toxic, nontoxic). (1,2) These patterns can be used to identify and prioritise the most promising molecules likely to have desirable physicochemical properties, most often biological activity against a pharmacological target of interest.
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R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers - Nature Communications

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By Chi Zhang, Yu-Jing Lu, Bingjie Chen, Zhiyan Bai, Qiaoxi Zeng, Alexia Hervieu, Marco P. Licciardello, Konstantinos Mitsopoulos, Bissan Al-Lazikani, Marcello Tortorici, Olivia Rossanese, Paul Workman, Paul Clarke Verified
| Nature Verified
Abstract Oestrogen receptor (ER) activation leads to the formation of DNA double strand breaks (DSB), promoting genomic instability and tumour heterogeneity. The single-stranded DNA cytosine deaminase APOBEC3B (A3B) serves as a co-activator of ER and is implicated in inducing DSBs at transcriptional enhancers regulated by ER.
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Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants - Nature Communications

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By Raymond Kiu, Elizabeth Darby, Paul Clarke Verified, Willem van Schaik
| Nature Verified
Abstract Preterm infants (<37 weeks’ gestation) are commonly given broad-spectrum antibiotics due to their risk of severe conditions like necrotising enterocolitis and sepsis. However, antibiotics can disrupt early-life gut microbiota development, potentially impairing gut immunity and colonisation resistance. Probiotics (e.g., certain Bifidobacterium strains) may help restore a healthy gut microbiota.
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