iPSCs were derived according to the protocol described previously (Salikhova et al., 2020). Donor skin biopsy collection was approved by the Institutional Ethics Committee of the Research Centre for Medical Genetics (Protocol No. 2019-2/3 from October 13, 2020). All patients given written informed consent for using the tissue for research purposes. CTS CytoTune-iPS 2.1 Sendai reprogramming kit (Invitrogen, Carlsbad, CA, USA) were used for fibroblast reprogramming.