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Articles by Lee KW
Protective effect of extracts of Perilla frutescens treated with sucrose on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in vitro and in vivo.
Abstract <p>Perilla frutescens leaves are often used in East Asian gourmet food. In this study, we investigated the hepatoprotective effects of P. frutescens leaves grown in different concentrations of sucrose (0, 115, 175 and 235 mM sucrose) leading to four samples of perilla leaf extracts (PLEs).
Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer
Investigation and validation of prognostic features associated with transient receptor potential channel genes in gastric cancer 1Department of Radiotherapye, The Second Hospital of Lanzhou University, Lanzhou, China 2Department of Oncology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou City, Gansu Province, China 3Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, China DOI 10.7717/peerj.21468 Academic Editor Lesley Anson Subject...
Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation
Yi Xian Foong conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Ning Yi Yap conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft. Kein Seong Mun performed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.
Jazz Pharmaceuticals to Present Data at ASCO 2026 Highlighting Advancements for Ziihera® (zanidatamab-hrii) in Gastroesophageal Adenocarcinoma and Zepzelca® (lurbinectedin)
Rapid oral presentation of PD-L1 subgroup data from HERIZON-GEA-01 evaluating zanidatamab combinations, and additional analyses of tolerability, biomarker response and real-world treatment patterns in HER2+ GEA For U.S. media and investors only DUBLIN, April 21, 2026 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the Company and its partners will present three rapid oral and seven poster presentations at the American Society of Clinical Oncology (ASCO) Annual...
Genome-wide association study identifies GAK and KLF12 associated with curve severity of adolescent idiopathic scoliosis
Zhicheng Dai conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Zhichong Wu performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Leilei Xu conceived and designed the experiments, analyzed the data, authored or reviewed drafts of the article, and approved the final draft.
Evaluation of the retreatability of bioceramic root canal sealers with various formulations in simulated grooves
Bioceramic-based sealers are notable for their biocompatibility and antimicrobial properties; however, their strong chemical bonding to dentin presents challenges during removal (Arul et al., 2022). This study evaluated the effectiveness of the removal of five different calcium silicate based sealers from artificially created grooves in oval-shaped canals using passive ultrasonic irrigation.
Relationship between heart rate variability parameters and inflammatory activity in patients with Crohn’s disease: a retrospective study
The aim of this study was to explore the relations between HRV parameters and the CDAI. Through several adjustment models and trend tests, we observed that HRV parameters were generally negatively correlated with the CDAI, among which TP, HF, and SDNN were significantly negatively correlated with the CDAI. Smooth curve fitting showed that there was a linear relation between HF and the CDAI: as HF increased, the CDAI decreased.
Clinical diagnosis, treatment, and survival analysis of 61 cases of salivary duct carcinoma: a retrospective study
1Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi Province, China 2Academy of Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi Province, China 3First Clinical Medical School, Shanxi Medical University, Taiyuan, Shanxi Province, China 4School of Stomatology, Shanxi Medical University, Taiyuan, Shanxi...
Association between fetal sex and metabolic syndrome in women aged 40 years and older: the REACTION study
This cross-sectional study was derived from the REACTION study (Ning & Reaction Study Group, 2012), a longitudinal study in China investigating the risk of cancer in Individuals with diabetes, which was performed between April and November 2011 by the Chinese Medical Association endocrine branch. Participants aged 40 and older were enrolled from five Luzhou communities using a multistage cluster random sampling method.
The effect of gene polymorphism on ticagrelor metabolism: an in vitro study of 22 CYP3A4 variants in Chinese Han population
Ticagrelor (99% purity) was purchased from Shanghai Canspec Scientific & Technology Co., Ltd (Shanghai, China). Deshydroxyethoxy Ticagrelor (AR-C124910XX, 98% purity) was purchased from Toronto Research Chemicals Inc (Toronto, Ontario, Canada). The internal standard (IS) carbamazepine (98% purity) was obtained from Sigma-Aldrich Company (St. Louis, Mo, USA). Reduced NADPH was supplied by Roche (Basel, Switzerland).
Construction and validation of a prognostic model for gastric cancer patients with tumor deposits
Construction and validation of a prognostic model for gastric cancer patients with tumor deposits 1Department of General Surgery, The Yijishan Hospital of Wannan Medical College, Wuhu, China 2Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China 3Department of Vascular Surgery, Drum Tower Hospital, Jiangsu, China DOI 10.7717/peerj.17751 Academic Editor Fanglin Guan Subject Areas Gastroenterology and Hepatology, Oncology, Translational Medicine...
Development and validation of a multi-parameter nomogram for venous thromboembolism in gastric cancer patients: a retrospective analysis
A clinical prediction model based on eight variables was established for the occurrence of VTE in GC. All eight variables, including age, KPS, blood transfusion, clinical stage, CVC, operation, FDP, and D-dimer, were included in this prediction model, which can be easily collected in clinical practice. This model’s discrimination, calibration, and prediction value are outstanding and have good application value in clinical recognition and decision-making.
Generation and characterization of mAb 61H9 against junctional adhesion molecule-a with potent antitumor activity
Generation and characterization of mAb 61H9 against junctional adhesion molecule-a with potent antitumor activity 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan, China 2Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China 3School of Basic...
Foxa2 attenuates steatosis and inhibits the NF-κB/IKK signaling pathway in nonalcoholic fatty liver disease
Twenty-four male C57BL/6 mice (four-week-old), obtained from GemPharmatech Co. Ltd. (Nanjing, China), were used to build the NAFLD mouse model. They were maintained in a controlled room with the temperature at 22–25 °C, a humidity of 55% ± 5%, and 12 h light/dark cycle. One week later, mice were randomly divided into four groups (n = 6): control, high-fat diet (HFD), HFD + overexpression negative control (oe-NC), and HFD + oe-Foxa2.
Carbon monoxide poisoning: beyond survival - mortality, morbidities, and risk factors, a Turkey sample
The rate of intentional CO poisoning cases is rare in Turkey. Only 0.3% of cases were found to be intentional in one study (Akkose et al., 2010).
Energy flow in men’s javelin throw and its relationship to joint load and performance
The most important factor in javelin throwing in order to reach longer throwing distances is the release speed. While other factors like the release angle, angle of attack and angle of yaw are also important and should be optimized according to the surrounding conditions, the release speed is the only factor that has to be maximized (Bartonietz, 2000; Krzyszkowski & Kipp, 2021).
MiR-155-5p Elevated by Ochratoxin A Induces Intestinal Fibrosis and Epithelial-to-Mesenchymal Transition through TGF-β Regulated Signaling Pathway In Vitro and In Vivo - PubMed
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Auxiliary liver xenotransplantation technique in a transgenic pig-to-non-human primate model: A surgical approach to prolong survival
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ILUSTRO: Phase 2 Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2-Positive Gastric or Gastroesophageal Junction Adenocarcinoma - PubMed
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An Alternative Treatment for Uterine Fibroids and Adenomyosis: High-intensity Focused Ultrasound
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Assessment of Risks and Benefits of Using Antibiotics Resistance Genes in Mesenchymal Stem Cell-Based Ex-vivo Therapy
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Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
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Radiologic Extranodal Extension of Metastatic Lymph Nodes in Patients With Non-Small Cell Lung Cancer: Prognostic Utility and Diagnostic Performance
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Parnassin, a Novel Therapeutic Peptide, Alleviates Skin Lesions in a DNCB-Induced Atopic Dermatitis Mouse Model
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A Phase 3 Randomized Clinical Trial to Compare Efficacy and Safety between Combination Therapy and Monotherapy in Elderly Patients with Advanced Gastric Cancer (KCSG ST13-10) - PubMed
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Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis
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Cinnamaldehyde-Rich Cinnamon Extract Induces Cell Death in Colon Cancer Cell Lines HCT 116 and HT-29
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Physicochemical and Biopharmaceutical Controllability of New Self-Assembled Fatty Acid Conjugated Leuprolide for the Enhanced Anticancer Activity
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Increased death and exhaustion of CD69high T cells and NK cells are associated with PD-1 antibody application in the in vitro co-culture system
Introduction Non-small cell lung cancer (NSCLC) is one of the malignant diseases with high morbidity (Kaur et al., 2021). Since most patients with advanced NSCLC lose the opportunity for surgical resection, they often require anti-tumor immunotherapy, such as anti-programmed cell death-1 (PD-1) immunotherapy (Shepherd, Douillard & Blumenschein, 2011). However, some of them do not benefit from the targeted PD-1 immunotherapy in clinic.
Investigation of Macrocyclic mTOR Modulators of Rapamycin Binding Site via Pharmacoinformatics Approaches
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Toxic effects of the wastewater produced by underwater hull cleaning equipment on the copepod Tigriopus japonicus
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Gut-on-a-Chip for the Analysis of Bacteria-Bacteria Interactions in Gut Microbial Community: What Would Be Needed for Bacterial Co-Culture Study to Explore the Diet-Microbiota Relationship? - PubMed
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Cigarette smoking induces the activation of RIP2/caspase-12/NF-κB axis in oral squamous cell carcinoma
Additional Information and Declarations Competing Interests The authors declare there are no competing interests. Author Contributions Yajie Qian conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.
Quantitative proteomic analysis of HER2 expression in the selection of gastric cancer patients for trastuzumab treatment
Gastric cancer (GC) accounts for 10% of cancer deaths worldwide [1]; median survival is 10–12 months in advanced cases [2]. Chemotherapy is the standard treatment of the majority of GC patients, however a subset of patients who harbor HER2 amplification are candidates for HER2-targeted therapy.
Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf
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