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Summary NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its NLR counterparts with unique features that mediate atypical functions compared with traditional NOD‐like receptors (NLRs). Aside from a mitochondrial targeting sequence, the N‐terminal region is yet to be characterized.
Highlights • MitoCDNB is a mitochondria-targeted molecule that disrupts thiol redox state • The CDNB moiety depletes glutathione and inhibits key thiol redox enzymes • MitoCDNB selectively disrupts mitochondrial thiol redox state in cells and in vivo • MitoCDNB extends methods available to investigate mitochondrial thiol redox state Summary Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell.
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